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      產品分類 > 抗腎小球基底膜疾病 > Intrinsic Factor/內因子

      Intrinsic Factor/內因子

      產品貨號:16700/16701
      促銷: 0.00

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      0.1mg 1mg
      德國Diarect

      Intrinsic Factor

       

      Diseases:
      Pernicious Anemia 

      Circulating antibodies against gastric intrinsic factor (IF) are highly specific and of high diagnostic relevance for pernicious anemia. Two types of clinically important autoantibodies can be measured: (i) so-called blocking antibodies which prevent the binding of vitamin B12 to the IF molecule; they are present in >50% of all patients with Biermer anemia; (ii) other types of antibodies to IF may interfere with the binding of the IF-Vit B12complex to the ileal receptor and are less common and sensitive.

      Intrinsic factor is produced by DIARECT in the baculovirus / Sf9 insect cell expression system. This high-quality antigen is secreted from the insect cell along the endosomal pathway via Golgi glycosylation and passes into the culture medium. Endogenous bound cobalamin/vitamin B12 is depleted during the purification process, exposing all relevant epitopes for autoantibody binding on the recombinant intrinsic factor.

       

      相關疾?。簮盒载氀?/span>

      惡性貧血(PA)是一種自身免疫紊亂導致神經上的改變的疾病。包括癡呆和與缺乏維生素B12相關的貧血疾病。當出現內因子的自身抗體或者通過干擾胃壁細胞的吸收減少內因子的水平時,惡性貧血患者會發生缺乏維生素B12的癥狀。    抗胃內因子(IF)的循環抗體具有高特異性及與惡性貧血的診斷相關性。臨床上可以堅測兩種重要的自身抗體:(i)封閉抗體(阻止維生素B12結合內因子),在多于50%的惡性貧血患者體內可檢測到;(ii)其他類型的內因子抗體,可能會干擾IF-Vit-B12復合物結合回腸受體,這種比較不常見,不太敏感。

      DIARECT生產的內因子是在桿狀病毒/Sf9昆蟲細胞表達系統中表達。這個高品質的抗原是有昆蟲細胞通過高爾基體糖基化經胞內通路分泌出來到培養基中的。內源結合的維生素B12在純化過程中被去除,暴露出所有相關的表位供自身抗體結合。


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